|
Research shows that most Americans don't get the recommended daily allowances of
vitamins and minerals from their diets. 1 And, busy lifestyles take a
toll on nutrient stores of vitamins and minerals needed for optimal energy
production and healthy stress management. Requirements for nutritional support
of the body can be altered due to changes in nutritional availability, time
commitments, stress levels and energy requirements that individuals may
experience on a daily basis. 2,3
Water soluble nutrients such as the B-vitamins,
vitamin C and certain minerals are not stored in the body, and so require
constant replenishing. They're required to support daily energy levels, to form
neurotransmitters, hormones, and immune system substances, and to protect from
the effects of stress, aging, occasional sleeplessness and oxidative stress.*4
Natural phytonutrients such as lutein, zeaxanthin,
hesperidin and fruit extracts can round out the nutritional profile of a
high-quality multiple. 5-7
Multivitamin and mineral supplements have been clinically shown to enhance
many aspects of health.* 8 In order to provide optimal health
benefits, the supplement must provide a full range of essential vitamins and
minerals, at clinically effective levels, along with other nutrients that
provide targeted support to the body's organs and systems.*8
Most once-daily multivitamins are formulated to provide only the
recommended daily allowances (RDA), which is defined as the minimum
amount of a vitamin or mineral that is required to prevent a deficiency disease
(i.e., scurvy, rickets). 9 The RDAs are not necessarily the amount
required for optimum health.
Doctor's Choice multivitamins are formulated to provide essential
nutrients for energy, bone support, digestion, vision, healthy aging, blood
sugar metabolism, and immune health.*
Making Multivitamins Easier to Swallow
An online survey of 679 adults found that 40 percent of them had difficulty
swallowing pills. Factors that affected the perceived difficulty in swallowing
the pill included the size of the pill and the shape. 10
Comprehensive multivitamins, by their very nature, can be large tablets.
To make Doctor's Choice Daily Multiples easier to swallow, they are
coated using OrganiGlide Technology. This unique, OrganiGlide coating is
composed of organic spirulina and natural acacia gum that protects the nutrients
from light and moisture while helping the tablet slide down the esophagus.
Key Multivitamin Ingredients
Doctor's Choice Daily Multiples offer the following ingredients that are
key to good health:
| Ingredient |
Key Functions and Benefits |
| Vitamin A and
Beta-Carotene |
Helps support healthy skin and mucous membrane integrity; supports
healthy immune system responses; supports healthy bone growth and healthy
reproductive processes.* Beta-carotene, a precursor of vitamin A, is an
antioxidant and free radical fighter.* 11-14 Vitamin A
also supports the function of heart mitochondria (energy-producing cells)
and maintains the general health and vigor of epithelial cells.*13,15
|
| Vitamin C |
Necessary for the proper functioning of the immune system; antioxidant
and free radical fighter; assists with hormone synthesis; supports healthy
skin integrity; supports healthy iron absorption*16-19 Promotes
many metabolic reactions, particularly protein metabolism, including
formation of connective tissue* Vitamin C also provides protection for the
inner lining of the arteries.*20 |
| Vitamin D |
Supports healthy metabolism of calcium and phosphorus; supports the
absorption of vitamin A; supports bone
mineralization* 21-23Recent research has shown that Vitamin D
is important to the maintenance of electrolyte balance, volume balance and
helps support the retention of healthy blood pressure levels that are
already within normal limits.* 24-26 Also boosts immune
function.* 27 |
| Vitamin E |
Helps oxygen circulation; supports healthy nerve transmissions; supports
healthy leg nerves and muscles; helps boost energy levels* 28-30
Vitamin E also inhibits the oxidation of low density lipids by inactivating
free radicals.*29 It supports fatty acids and healthy development
of cell structures. 33 Supports healthy platelet activity*29,31
|
| Potassium |
Supports healthy nervous system; supports regular heart rhythm; supports
proper muscle contraction, especially cardiac muscle contraction* 32-34
|
| Bilberry (Vaccinium myrtillus) |
Rich in flavonoids and supports eye health* 35 |
| Lutein |
Lutein scavenges free reactive oxidative species, supports eye health,
and may support healthy cholesterol levels already within normal limits*
5,36-38 |
| Lycopene |
An antioxidant that provides protection to the inside surfaces of artery
walls* Assists in cholesterol metabolism* 39,40 |
| Vegetable Blend |
Vegetables are important sources of antioxidants.* Cruciferous
vegetables contain glucosinolates, which are important for cellular health.
41,42 Cruciferous vegetables, such as broccoli, cauliflower, and
cabbage, contain several phytochemicals including indole-3-carbinol (I3C),
phenethyl isothiocyanate (PEITC), sulforaphane, and diindolylmethane (DIM).
43-47 These cruficerous vegetables are important for healthy
hormone metabolism.*47,48 |
Ingredients for Digestion*
Doctor's Choice provides the following ingredients to promote healthy
digestion:*
| Ingredient |
Key Functions and Benefits |
| Betaine |
Works with B vitamins to synthesize amino acids, precursor to SAM-e.*
49,50 |
| Ginger |
Supports body's anti-inflammatory response; supports healthy stomach
function.* 51,52 |
Ingredients for Blood Sugar Metabolism*
Doctor's Choice provides the following ingredients to support blood sugar
metabolism already within the normal range:*
| Ingredient |
Key Functions and Benefits |
| Chromium |
Supports healthy carbohydrate metabolism; helps maintain healthy blood
glucose concentration already within normal range; may increase insulin
binding and the number of insulin receptors.* 53,54 Helps support
the retention of healthy cholesterol levels that are already within normal
limits.*53,54 |
| Vanadium |
An essential trace element, vanadium supports glucose and lipid
metabolism* Vanadium adds support to sodium and potassium transport in the
red blood cell.* 55-57 |
| Cinnamon Bark |
Supports healthy immune system; helps maintain healthy blood glucose
metabolism already within normal limits; supports healthy digestion;
supports healthy bacterial balance in the intestines.* 58-60 |
Ingredients for Healthy Aging and Immunity*
Doctor's Choice provides the following ingredients to support healthy
aging and immunity:*
| Ingredient |
Key Functions and Benefits |
| Iodine |
Required by thyroid gland to synthesize thyroid hormones, which regulate
the basal metabolic rate; the thyroid gland is critically linked to
effective cardiac functioning.* 61 Contributes to the
efficiency of the pumping strength of the heart muscle; supports healthy
metabolic rate; supports healthy growth regulation.*61 |
| Zinc |
Supports healthy immune system; supports healthy enzyme processes;
supports healthy immune response* 62
Involved in protein digestion; Zinc has been shown in clinical trials to
support healthy aortic valves and overall cardiovascular health.* 63
Supports prostate health in men* 64 |
| Selenium |
An essential trace element; with vitamin E supports healthy cell
membranes; supports healthy thyroid
functioning* 65-68Research also shows that selenium supports
cardiovascular function.* 69
Supplementation of selenium has been shown to promote prostate health.*70
|
| Copper |
Supports healthy energy metabolism, healthy skin integrity; helps iron
utilization; required with iron for synthesis of hemoglobin.* 71,72
Provides significant support for healthy heart muscles.* 73-75
Component of coenzymes in electron transport chain and enzyme necessary
for melanin pigment formation.*71,72 |
| Manganese |
Supports healthy metabolic reactions; activates several enzymes and has
antioxidant properties; needed for hemoglobin synthesis, urea formation,
growth, reproduction, lactation, bone formation, possibly the production and
release of insulin and inhibiting cell damage.* 76,77 |
| Chromium |
Supports healthy carbohydrate metabolism; helps maintain healthy blood
glucose concentration already within normal range; may increase insulin
binding and the number of insulin receptors.* 78,79 Helps support
the retention of healthy cholesterol levels that are already within normal
limits.*78,79 |
| Molybdenum |
Supports healthy iron metabolism; supports healthy uric acid production;
supports healthy sexual functioning
in men* 80,81 Functions as a cofactor for three enzymes which
contribute to the antioxidant capacity of the blood and also plays a role in
the metabolism of prescription medications.*80,81 |
| Boron |
Supports healthy bone and joint function; supports healthy muscle
health; supports healthy muscle synthesis* 82 |
| Green Tea |
Polyphenols in green tea act as potent antioxidants; supports cellular
health.*83 |
| Sweet Cherry Fruit Extract |
Rich in antioxidants and supports the immune system.* 84,85
|
| Inositol |
Supports healthy nerve cell transmission.*86,87 |
| Pomegranate (40% ellagic acid) |
Pomegranate is a polyphenol antioxidant; fights free radicals; promotes
prostate and breast cell health.* 88,89 |
| Polygonnum Cuspitadium, 50% Resveratrol |
A potent antioxidant; supports healthy aging and cardiovascular health.*
90,91 |
Ingredients for Bone Health*
Doctor's Choice provides the following ingredients for bone health:*
| Ingredient |
Key Functions and Benefits |
| Calcium |
Necessary for bone and joint health;* allows proper interaction of
myosin and actin, proteins in the muscles, to support proper contraction*
92-95 |
| Magnesium |
Magnesium regulates nerve muscle firing.* 96-99 Required for normal
functioning of muscle and nervous tissue; participates in bone formation;*
constituent of many coenzymes.97,98 Supports a healthy immune
system and enzymes involved in energy production*96-99 |
| Selenium |
An essential trace element; with vitamin E supports healthy cell
membranes; supports healthy thyroid functioning* 100-103
Research also shows that selenium supports cardiovascular function.*104
Supplementation of selenium has been shown to promote prostate health.*
105 |
| Manganese |
Supports healthy metabolic reactions; activates several enzymes and has
antioxidant properties; needed for hemoglobin synthesis, urea formation,
growth, reproduction, lactation, bone formation, possibly the production and
release of insulin and inhibiting cell damage.* 106,107 |
| Boron |
Supports healthy bone and joint function; supports healthy muscle
health; supports healthy muscle synthesis*108 |
Ingredients for Energy*
Doctor's Choice provides the following ingredients for energy:*
| Ingredient |
Key Functions and Benefits |
| Thiamin (Vitamin B1) |
Essential for carbohydrate metabolism; important for immune system
functioning; affects mood and cognitive function* 109,110
Essential for synthesis of acetycholine*111 |
| Riboflavin (Vitamin B2) |
Riboflavin (vitamin B2) is crucial in the production of body energy.*
Supports healthy glutathione reductase activity, which helps maintain
glutathione, a major protector against free radical damage.* Vitamin B2
itself also has antioxidant
qualities.* 112-114 |
| Niacin |
Supports healthy cholesterol production and assists in triglyceride
breakdown to retain healthy cholesterol levels that are already within
normal limits*115-119 Increases good cholesterol levels,
particularly HDL-2 (the best cholesterol).*120
Niacin supports the retention of healthy blood pressure that is already
within normal limits.*121 |
| Vitamin B6 |
A homocysteine lowering agent that also supports healthy circulation.*122,123
Essential coenzyme for normal
amino acid metabolism; assists in production of circulating
antibodies* 124 |
| Folic Acid |
Folic acid's main function is support of healthy energy production.* It
supports healthy immune system and healthy nervous system function.* Recent
research shows folic acid can reduce the amount of the amino acid
homocysteine in
the blood.* 125-128 |
| Vitamin B12 |
This essential nutrient supports healthy human energy production.*
Vitamin B12 helps support metabolism of carbohydrates and fats.* It supports
healthy cell formation and cellular longevity.*128-130 |
| Biotin |
Essential coenzyme required by the mitochondria for cellular production
of energy.* 143 Required for the conversion of pyruvic acid to
oxaloacetic acid and the synthesis of fatty acids and purines; supports
healthy hair and skin.*131-133 |
| Pantothenic Acid |
In clinical studies, when combined with other heart healthy nutrients,
pantothenic acid supported the muscle strength of the heart.*134
Essential for transfer of pyruvic acid into Krebs cycle, conversion of
lipids and amino acids into glucose, and synthesis of cholesterol and
steroid hormones*135 |
| Choline Bitartrate |
Choline contains methyl group, and methyl groups from choline convert
homocysteine into a useful amino acid.*136 Choline is important
for the structural integrity of cell membranes and lipid and cholesterol
transport and metabolism.* 137,138 |
References:
- White E, Patterson RE, Kristal AR, Thornquist M, King I, Shattuck AL,
Evans I, Satia-Abouta J, Littman AJ, Potter JD. Vitamins and lifestyle cohort
study: study design and characteristics of supplement users. Am J Epidemiol.
2004 Jan 1;159(1):83-93.
- Murphy SP, Allen LH. Nutritional importance of animal source foods. J
Nutr. 2003 Nov;133(11 Suppl 2):3932S-3935S.
- Alexy U, Sichert-Hellert W, Kersting M. Associations between intake of
added sugars and intakes of nutrients and food groups in the diets of German
children and adolescents. Br J Nutr. 2003 Aug;90(2):441-7.
- Hultman E, Harris RC, Spriet LL. Energy substrates available for work. In:
Shils ME, Olson JA, Shine M, Ross AC, Eds. Modern Nutrition in Health and
Disease 9th ed. Baltimore, Md: Lippincott Williams & Wilkins; 1999:
762-764.
- Granado F, Olmedilla B, Blanco I. Nutritional and clinical relevance of
lutein in human health. Br J Nutr. 2003;90(3):487-502.
- Ou S. Pharmacological action of hesperidin. Zhong Yao Cai.
2002;25(7):531-3.
- Duthie GG, Gardner PT, Kyle JA. Plant polyphenols: are they the new magic
bullet? Proc Nutr Soc. 2003;62(3):599-603.
- Bendich A, Mallick R, Leader S. Potential health economic benefits of
vitamin supplementation. West J Med. 1997 May;166(5):306-12.
- Lachance PA. International perspective: Basis, need, and application of
Recommended Dietary Allowances. Nutr Rev. 1998;56:S2-S4.
- 40% Of American Adults Report Experiencing Difficulty Swallowing Pills.
Reported in: Swallowing an underestimated problem in adults, says survey.
Available at: http://www.in-pharmatechnologist.com/news/ng.asp?id=49124-swallowing-an-underestimated.
Accessed on November 6, 2007.
- Berdanier CD, Everts HB, Hermoyian C, Mathews CE. Role of vitamin A in
mitochondrial gene expression. Diabetes Res Clin Pract. 2001;54:S11-27.
- Bates CJ. Vitamin A. Lancet. 1995;345:31-35.
- Ross AC. Vitamin A and retinoids. In: Shils ME, Olson JA, Shine M, Ross
AC, Eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, Md:
Lippincott Williams & Wilkins; 1999:305-328.
- Everts HB, Claassen DO, Hermoyian CL, Berdanier CD. Nutrient-gene
interaction: dietary vitamin A and mitochondrial gene expression. IUBMB
Life. 2002;6:295-301.
- Tortora GJ, Grabowski SR. Principles of Anatomy and Physiology. 8th
ed. New York, NY. Harper and Row. 1996:837-838.
- Nieman DC, Henson DA, McAnulty SR, et al. Influence of vitamin C
supplementation on oxidative and immune changes after an ultramarathon. J
Appl Physiol. 2002;92:1970-7. 2.
- Li X, Cobb CE, Hill KE, Burk RF, May JM. Mitochondrial uptake and
recycling of ascorbic acid. Arch Biochem Biophys. 2001;387:143-53.
- Jacob RA. Vitamin C. In: Shils ME, Olson JA, Shine M, Ross AC, Eds.
Modern Nutrition in Health and Disease. 9th ed. Baltimore, Md: Lippincott
Williams & Wilkins; 1999:467-483.
- NCI FACT SHEET: Antioxidants and cancer prevention. Available at: http://www.cancer.gov/newscenter/pressreleases/antioxidants.
Accessed October 28, 2003.
- Fleming T., ed. Vitamin C. In: PDR for Nutritional Supplements.
Montvale, NJ: Medical Economics Company; 2001: 486-498.
- Brown AJ. Therapeutic uses of vitamin D analogues. Am J Kidney Dis.
2001;3:S3-S19.
- Miller WL, Portale AA. Genetics of vitamin D biosynthesis and its
disorders. Best Pract Res Clin Endocrinol Metab. 2001;15:95-109. 28.
- Fleming T., ed. Vitamin D. In: PDR for Nutritional Supplements.
Montvale, NJ: Medical Economics Company; 2001: 498-505.
- Chun Li Y, Kong J, Wei M, et al. 1,25-Dihydroxyvitamin D3 is a negative
endocrine regulator of the renin-angiotension system. J Clin Invest.
2002;110:229-238.
- Tukaj C, Kubasik-Juraniec J, Kraszpulski M. Morphological changes of
aortal smooth muscle cells exposed to calcitrol in culture. Med Sci Monit.
2000;4:668-674.
- Charniot JC, Alexeeva A, Laurent S. Reversible hypokinetic cardiomyopathy
revealing severe hypocalcemia. Arch Mal Coeur Vaiss. 2001;7:747-50.
- Holick MF. Vitamin D deficiency. N Engl J Med. 2007 Jul
19;357(3):266-81.
- Ebrahim AS, Babu E, Thirunavukkarasu C, Sakthisekaran D. Protective role
of vitamin E, 2-deoxy-D-glucose, and taurine on perchloroethylene induced
alterations in ATPases. Drug Chem Toxicol. 2001;24:429-37.
- Traber MG, Arai H. Molecular mechanisms of vitamin E transport. Annu
Rev Nutr. 1999;19:343-55.
- Fleming T., ed. Vitamin E. In: PDR for Nutritional Supplements.
Montvale, NJ: Medical Economics Company; 2001: 505-522.
- Canbaz S, Duran E, Ege T, et al. The effects of intracoronary
administration of vitamin E on myocardial ischemia-reperfusion injury during
coronary artery surgery. Thorac Cardiovasc Surg. 2003; 2:57-61.
- Fleming T., ed. Potassium. In: PDR for Nutritional Supplements.
Montvale, NJ: Medical Economics Company; 2001:368-372.
- Young DB, Lin H, McCabe RD. Potassium's cardiovascular protective
metabolism. Am J Physiol. 1995;268:825-837.
- Young DB, Ma G. Vascular protective effects of potassium. Semin Nephrol.
1999;19:477-486.
- Fleming T., ed. Bilberry. In: PDR for Herbal Supplements. Montvale,
NJ: Medical Economics Company; 2000:75-78.
- Semba RD, Dagnelie G. Are lutein and zeaxanthin conditionally essential
nutrients for eye health? Med Hypotheses. 2003;4:465-72. 2.
- Linseisen J, Hoffmann J, Reidl J, Wolfram G. Effect of a single oral dose
of antioxidant mixture (vitamin E, carotenoids) on the formulation of
cholesterol oxidation products after ex vivo DDL oxidation in humans. Eur J
Med Res. 1998;1-2:5-12.
- Lowe GM, Bilton RF, Davies IG, et al. Carotenoid composition and
antioxidant potential in subfractions of human low-density lipoprotein. Ann
Clin Biochem. 1999;36:323-32.
- Sesso HD, Liu S, Gaziano JM, Buring JE. Dietary lycopene, tomato-based
food products and cardiovascular disease in women. J Nutr.
2003;133:2336-2341.
- Arab L, Steck S. Lycopene and cardiovascular disease. Am J Clin Nutr.
2000;71:1691S-1695S.
- Talalay P, Fahey JW. Phytochemicals from cruciferous plants protect
against cancer by modulating carcinogen metabolism. J Nutr. 2001
Nov;131(11 Suppl):3027S-33S.
- Brennan P, Hsu CC, Moullan N, Szeszenia-Dabrowska N, Lissowska J, Zaridze
D, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, Gemignani
F, Chabrier A, Hall J, Hung RJ, Boffetta P, Canzian F. Effect of cruciferous
vegetables on lung cancer in patients stratified by genetic status: a
mendelian randomisation approach. Lancet. 2005 Oct 29-Nov
4;366(9496):1558-60.
- Verhoeven DT, Goldbohm RA, van Poppel G, Verhagen H, van den Brandt PA.
Epidemiological studies on brassica vegetables and cancer risk. Cancer
Epidemiol Biomarkers Prev. 1996;5:733-748.
- Kolonel LN, Hankin JH, Whittemore AS, et al. Vegetables, fruits, legumes
and prostate cancer: a multiethnic case-control study. Cancer Epidemiol
Biomarkers Prev. 2000;9:795-804.
- Fahey JW, Zhang Y, Talalay P. Broccoli sprouts: an exceptionally rich
source of inducers of enzymes that protect against chemical carcinogens.
Proc Natl Acad Sci U S A. 1997;94:10367-72.
- Brooks JD, Paton VG, Vidanes G. Potent induction of phase 2 enzymes in
human prostate cells by sulforaphane. Cancer Epidemiol Biomarkers Prev.
2001;10:949-954.
- Jellinck PH, Forkert PG, Riddick DS, Okey AB, Michnovicz JJ, Bradlow HL.
Ah receptor binding properties of indole carbinols and induction of hepatic
estradiol hydroxylation. Biochem Pharmacol. 1993;45:1129-36.
- Le HT, Schaldach CM, Firestone GL, Bjeldanes LF. Plant-derived
3,3'-Diindolylmethane is a strong androgen antagonist in human prostate cancer
cells. J Biol Chem. 2003;278:21136-45.
- Selhub J. Homocysteine metabolism. Annu Rev Nutr. 1999;19:217-46.
90.
- Barak AJ, Beckenhauser HC, Tuma DJ. Betaine, ethanol, and the liver: a
review. Alcohol. 1996;13(4):395-8.
- Grzanna R, Lindmark L, Frondoza CG. Ginger—an herbal medicinal product
with broad anti-inflammatory actions. J Med Food. 2005
Summer;8(2):125-32.
- Fleming T., ed. Ginger. In: PDR for Herbal Supplements. Montvale,
NJ: Medical Economics Company; 2000:362-367.
- Fleming T., ed. Chromium. In: PDR for Nutritional Supplements.
Montvale, NJ: Medical Economics Company; 2001:96-100.
- Vincent J. The biochemistry of chromium. J Nutr. 2000;130:715-718.
- Barceloux DG. Vanadium. J Toxicol Clin Toxicol. 1999;2:265-78.
- Carmignani M, Volpe AR, Masci O, et al. Vanadate as factor of
cardiovascular regulation by interactions with the catecholamine and nitric
oxide systems. Biol Trace Elem Res. 1996;1:1-12.
- Wardlaw GM, Insel PM. Perspectives in Nutrition. 2nd ed. St. Louis,
MO: Mosby; 1993:482-3.
- Senhaji O, Faid M, Kalalou I. Inactivation of Escherichia coli O157:H7 by
essential oil from Cinnamomum zeylanicum. Braz J Infect Dis. 2007
Apr;11(2):234-6.
- Solomon TP, Blannin AK. Effects of short-term cinnamon ingestion on in
vivo glucose tolerance. Diabetes Obes Metab. 2007 Nov;9(6):895-901.
- Fleming T., ed. Cinnamon. In: PDR for Herbal Supplements. Montvale,
NJ: Medical Economics Company; 2000:199-201.
- Hetzel BS, Clugston GA. Iodine. In: Shils ME, Olson JA, Shine M, Ross AC,
Eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, Md:
Lippincott Williams & Wilkins; 1999:253-264.
- Lastra MD, Pastelin R, Camacho A, Monroy B, Aguilar AE. Zinc intervention
on macrophages and lymphocytes response. J Trace Elem Med Biol.
2001;15:5-10.
- Micheletti A, Rossi R, Rufini S. Zinc status in athletes: relation to diet
and exercise. Sports Med. 2001;31:577-82.
- Liang JY, Liu YY, Zou J, Franklin RB, Costello LC, Feng P. Inhibitory
effect of zinc on human prostatic carcinoma cell growth. Prostate. 1999
Aug 1;40(3):200-7.
- Combs GF Jr. Impact of selenium and cancer-prevention findings on the
nutrition-health paradigm. Nutr Cancer. 2001;40:6-11.
- Brown KM, Arthur JR. Selenium, selenoproteins and human health: a review.
Public Health Nutr. 2001 Apr;4(2B):593-9.
- Patel JC. Human health and selenium. Indian J Med Sci. 2000
Dec;54(12):563-6.
- Burk RF, Levander OA. Selenium. In: Shils ME, Olson JA, Shine M, Ross AC,
Eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, Md:
Lippincott Williams & Wilkins; 1999:262-276.
- Alissa EM, Bahijri SM, Ferns GA. The controversy surrounding selenium and
cardiovascular disease: a review of the evidence. Med Sci Monit.
2003;1:RA9-18.
- Giovannucci E. Selenium and risk of prostate cancer. Lancet.
1998;352:755-756.
- Turnland JR. Copper. In: Shils ME, Olson JA, Shine M, Ross AC, Eds.
Modern Nutrition in Health and Disease. 9th ed. Baltimore, Md: Lippincott
Williams & Wilkins; 1999:241-252.
- Fleming T., ed. Copper. In: PDR for Nutritional Supplements.
Montvale, NJ: Medical Economics Company; 2001: 112-114.
- Elsherif L, Ortines RV, Saari JT, Kang YJ. Congestive heart failure in
copper deficient mice. Exp Biol Med (Maywood). 2003;7:811-17.
- Medeiros DM, Wildman RE. Newer findings on a unified perspective of copper
restriction and cardiomyopathy. Exp Biol Med. 1997;215:299-313.
- Heller LJ, Mohrman DE, Prohaska JR. Decreased passive stiffness of cardiac
myocytes and cardiac tissue from copper deficient rat hearts. Am J Physiol
Heart Physiol.2000;8:H1840-H1847.
- Neilsen FH. Manganese. In: Shils ME, Olson JA, Shine M, Ross AC, Eds.
Modern Nutrition in Health and Disease. 9th ed. Baltimore, Md: Lippincott
Williams & Wilkins; 1999: 289-292. 77.
- Keen CL, Ensunsa JL, Watson MH, et al. Nutritional aspects of manganese
from experimental studies. Neurotoxicol. 1999;20:213-223.
- Fleming T., ed. Chromium. In: PDR for Nutritional Supplements.
Montvale, NJ: Medical Economics Company; 2001:96-100.
- Vincent J. The biochemistry of chromium. J Nutr. 2000;130:715-718.
- Neilsen FH . Molybdenum. In: Shils ME, Olson JA, Shine M, Ross AC, Eds.
Modern Nutrition in Health and Disease. 9th ed. Baltimore, Md: Lippincott
Williams & Wilkins;1999: 292-293.
- Mendel RR. The role of the molybdenum cofactor in humans. BioFactors.
2000;11:147-148.
- Nielsen FH. Boron. In: Shils ME, Olson JA, Shine M, Ross AC, Eds.
Modern Nutrition in Health and Disease. 9th ed. Baltimore, Md: Lippincott
Williams & Wilkins;1999: 286-288.
- Fleming T., ed. Green Tea. In: PDR for Herbal Supplements.
Montvale, NJ: Medical Economics Company; 2000:408-414.
- Havsteen B, Flavonoids: A class of natural products of high
pharmacological potency. Biochem Pharm. 1983;32:1141-1148
- Blando F, Gerardi C, Nicoletti I. Sour Cherry (Prunus cerasus L)
Anthocyanins as Ingredients for Functional Foods. J Biomed Biotechnol.
2004;2004(5):253-258.
- Colodny L, Hoffman RL. Inositol? Clinical applications for exogenous use.
Altern Med Rev. 1998;3:432-447.
- Fleming T., ed. Myo-inositol. In: PDR for Nutritional Supplements.
Montvale, NJ: Medical Economics Company; 2001:315-318.
- Pantuck AJ, Leppert JT, Zomorodian N, Aronson W, Hong J, Barnard RJ,
Seeram N, Liker H, Wang H, Elashoff R, Heber D, Aviram M, Ignarro L,
Belldegrun A. Phase II study of pomegranate juice for men with rising
prostate-specific antigen following surgery or radiation for prostate cancer.
Clin Cancer Res. 2006 Jul 1;12(13):4018-26.
- Jeune MA, Kumi-Diaka J, Brown J. Anticancer activities of pomegranate
extracts and genistein in human breast cancer cells. J Med Food. 2005
Winter;8(4):469-75.
- Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo
evidence. Nat Rev Drug Discov. 2006;5:493-506.
- Valenzano DR, Terzibasi E, Genade T, Cattaneo A, Domenici L, Cellerino A.
Resveratrol prolongs lifespan and retards the onset of age-related markers in
a short-lived vertebrate. Curr Biol. 2006;16:296-300.
- Heaney RP. Long-latency deficiency disease: insights from calcium and
vitamin D. Am J Clin Nutr. 2003;78(5):912-9.
- Wardlaw GM, Insel PM. Perspectives in Nutrition. 2nd ed. St. Louis,
MO: Mosby; 1993:437-447.
- Berridge MJ. Cardiac calcium signaling. Biochem Soc Trans.
2003;5:930-33.
- Fleming T., ed. Calcium. In: PDR for Nutritional Supplements.
Montvale, NJ: Medical Economics Company; 2001: 74-79..
- Shils ME. Magnesium In: Shils ME, Olson JA, Shine M, Ross AC, Eds.
Modern Nutrition in Health and Disease. 9th ed. Baltimore, Md: Lippincott
Williams & Wilkins; 1999:169-192. 59.
- Lourenco R, Camilo ME. Magnesium: physiological and clinical relevance. 1:
homeostasis and alterations in the metabolism of magnesium. Acta Med Port.
2000;13:211-20.
- Martini LA. Magnesium supplementation and bone turnover. Nutr Rev.
1999;57:227-9.,/li>
- Reinhart RA. Magnesium metabolism. Wis Med J. 1990 Oct;89:579-83.
- Combs GF Jr. Impact of selenium and cancer-prevention findings on the
nutrition-health paradigm. Nutr Cancer. 2001;40:6-11.
- Brown KM, Arthur JR. Selenium, selenoproteins and human health: a review.
Public Health Nutr. 2001 Apr;4(2B):593-9.
- Patel JC. Human health and selenium. Indian J Med Sci. 2000
Dec;54(12):563-6.
- Burk RF, Levander OA. Selenium. In: Shils ME, Olson JA, Shine M, Ross AC,
Eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore, Md:
Lippincott Williams & Wilkins; 1999:262-276.
- Alissa EM, Bahijri SM, Ferns GA. The controversy surrounding selenium and
cardiovascular disease: a review of the evidence. Med Sci Monit.
2003;1:RA9-18.
- Giovannucci E. Selenium and risk of prostate cancer. Lancet.
1998;352:755-756.
- Neilsen FH. Manganese. In: Shils ME, Olson JA, Shine M, Ross AC, Eds.
Modern Nutrition in Health and Disease. 9th ed. Baltimore, Md: Lippincott
Williams & Wilkins; 1999: 289-292. 77.
- Keen CL, Ensunsa JL, Watson MH, et al. Nutritional aspects of manganese
from experimental studies. Neurotoxicol. 1999;20:213-223.
- Nielsen FH. Boron. In: Shils ME, Olson JA, Shine M, Ross AC, Eds.
Modern Nutrition in Health and Disease. 9th ed. Baltimore, Md: Lippincott
Williams & Wilkins;1999: 286-288.
- Fleming T., ed. Thiamin. In: PDR for Nutritional Supplements.
Montvale, NJ: Medical Economics Company; 2001: 445-451.
- Woodlaw G, Insel P. Thiamin. In: Perspectives in Nutrition 2nd ed.
Mosby; St. Louis Mo., 1993; 382-384.
- Grodner M, Anderson SL, DeYoung S. Thiamin In: Foundations and Clinical
Applications of Nutrition: A Nursing Approach. St. Louis, MO: Mosby;
2000:175-177.
- McCormick DB. Riboflavin. In: Shils ME, Olson JA, Shine M, Ross AC, Eds.
Modern Nutrition in Health and Disease. 9th ed. Baltimore, Md: Lippincott
Williams & Wilkins; 1999:391-399.
- Heap LC, Peters TJ, Wessely S. Vitamin B status in patients with chronic
fatigue syndrome. J R Soc Med. 1999;92:183-5.
- Rokitzki L, Sagredos A, Keck E, Sauer B, Keul J. Assessment of vitamin B2
status in performance athletes of various types of sports. J Nutr Sci
Vitaminol (Tokyo). 1994;40:11-22.
- Robinson AW, Sloan HL, Arnold G. Use of niacin in the prevention and
management of hyperlipidemia. Prog Cardiovasc Nurs. 2001;1:14-20.
- Pearson TA. Divergent approaches to the treatment of dyslipidemia with low
levels of high-density lipoprotein cholesterol. Am J Cardiol.
2000;12A:57L-61L.
- White Robinson A, Sloan HL, Arnold G. The antilipidemic effects of plain
and extended-release niacin. Prev Cardiol. 2000;3:131-135.
- Chen MS, Bhatt DL. Highlights of the 2002 update to the 2000 American
College of cardiology/American Heart Association acute coronary syndrome
guidelines. Cardiol Rev. 2003;3:113-21.
- Monroe VS, Kerensky RA, Rivera E, Smith KM, Pepine CJ. Pharmocologic
plaque passivation for the reduction of recurrent cardiac events in acute
coronary syndromes. J AM Coll Cardiol. 2003; 41:23S-30S.
- Morgan JM, Carey CM, Lincoff A, Capuzzi DM. The effects of niacin on
lipoprotein subclass distribution. Prev Cardiol. 2004 Fall;7(4):182-7.
- Gadegbeku CA, Dhandayuthapani A, Shrayyef MZ, Egan BM. Hemodynamic effects
of nicotinic acid infusion in normotensive and hypertensive subjects. Am J
Hypertens. 2003;1;67-71.
- Schnyder G, Roffi M, Flammer Y, Pin R, Hess OM. Effect of homocysteine-lowering
therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after
percutaneous coronary intervention: the Swiss Heart study: a randomized
controlled trial. JAMA. 2002:8:973-9.
- O'Connor JJ, Meurer LN. Should patients with coronary disease and high
homocysteine take folic acid? J Fam Pract. 2003:52:7-8.
- Fleming T., ed. Vitamin B6. In: PDR for Nutritional Supplements.
Montvale, NJ: Medical Economics Company; 2001: 469-477.
- Joshi R, Adhikari S, Patro BS, Chattopadhyay S, Mukherjee T. Free radical
scavenging behavior of folic acid: evidence for possible antioxidant activity.
Free Radic Biol Med. 2001;30:1390-9.
- Rissanen PM, Laakkonen EI, Suntioinen S, Penttila IM, Uusitupa MI. The
nutritional status of Finnish home-living elderly people and the relationship
between energy intake and chronic diseases. Age Aging. 1996;25:133-8.
- Herbert V. Folic acid. In: Shils ME, Olson JA, Shine M, Ross AC, Eds.
Modern Nutrition in Health and Disease. 9th ed. Baltimore, Md: Lippincott
Williams & Wilkins; 1999:433-446.
- Fairfield KM, Fletcher RH. Vitamins for chronic disease prevention in
adults: scientific review. JAMA. 2002;287:3116-26.
- Masuda Y, Kokubu T, Yamashita M, Ikeda H, Inoue S. EGG phosphatidylcholine
combined with vitamin B12 improved memory impairment following lesioning of
nucleus basalis in rats. Life Sci. 1998;62:813-22.
- Weir DG, Scott JM. Vitamin B12 “Cobalamin,” In: Shils ME, Olson JA, Shine
M, Ross AC, Eds. Modern Nutrition in Health and Disease. 9th ed.
Baltimore, Md: Lippincott Williams & Wilkins; 1999: 457-458.
- Mock DM. Biotin. In: Shils ME, Olson JA, Shine M, Ross AC, Eds. Modern
Nutrition in Health and Disease. 9th ed. Baltimore, Md: Lippincott
Williams & Wilkins; 1999:459-466.
- Fleming T., ed. Biotin. In: PDR for Nutritional Supplements.
Montvale, NJ: Medical Economics Company; 2001: 50-55.
- Said HM. Biotin: the forgotten vitamin. Am J Clin Nutr. 2002
Feb;75(2):179-80.
- Vargiu R, Licheri D, Carcassi AM, et al. Enhancement of muscular
performance by a coformulation of propionyl-L-Carnitine, coenzyme Q10,
nicotinamide, riboflavin and pantothenic acid in the rat. Physiol Behav.
2002;2:257-63.
- Institute of Medicine. Pantothenic acid In: Dietary reference intakes for
thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic
acid, biotin, and choline. Washington D.C. The National Academy Press.
1999:357.
- Wood M. Folate and choline interplay investigated. Agricult Res.
2001;3:16-17.
- Zeisel SH, Mar MH, Howe JC, Holden JM. Concentration of choline-containing
compounds and betaine in common foods. J Nutr. 2003;5:1302-7.
- Institute of Medicine. Choline In: Dietary reference intakes for thiamin,
riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin,
and choline. Washington D.C. The National Academy Press. 1999:390.
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